[NTR] Mesenchymal lymphoid tissue organizer cell

[JABelfiore]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label
Mesenchymal lymphoid tissue organizer cell

Synonyms (add reference(s), please)

mLTo cells [PMID:31201308]

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

A mesenchymal cell located in the embryonic lymph node anlagen. This cell expresses lymphotoxin β receptor (LTβR) and vascular cell adhesion molecule (VCAM-1) and responds to signaling from lymphoid tissue inducer cells.
A mesenchymal lymphoid tissue organizer cell is capable of differentiating into various lymph node stromal cell subsets. This cell produces chemokines CCL19 and CCL21. This cell also expresses fibroblast activation protein-α (FAP) during early development[PMID:29435977][PMID:31201308].

Extended: Critical for lymph node development and organization. Interacts with lymphoid tissue inducer cells to initiate lymph node formation. Precursor to adult lymph node stromal cells including fibroblastic reticular cells, follicular dendritic cells, and marginal reticular cells. Activation and differentiation are dependent on LTβR signaling and NF-κB pathways. Contributes to the establishment of distinct microenvironments within developing lymph nodes[PMID:31201308][PMID:29435977].

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)

Mesenchymal progenitor cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Your ORCID
https://orcid.org/0009-0005-7919-4905

Additional notes or concerns

[dosumis]

Doesn't look quite right we need cell in adult gut.

[dosumis]

https://www.perplexity.ai/search/what-is-known-about-the-sturct-BEDqQGfIRHK3MOx_1NEbNA

[dosumis]

actually got a slightly more relevant looking answer on the second question here: https://www.perplexity.ai/search/provide-mlto-fibroblasts-tBBLTiRmRmua3PfUubhsKg

(ignore first)