diff --git a/.github/workflows/wheel-builder.yml b/.github/workflows/wheel-builder.yml
index 1643b22b26a6..f1b92b5b9eca 100644
--- a/.github/workflows/wheel-builder.yml
+++ b/.github/workflows/wheel-builder.yml
@@ -107,9 +107,6 @@ jobs:
           sparse-checkout: |
             ${{ env.BUILD_REQUIREMENTS_PATH }}
           sparse-checkout-cone-mode: false
-      - run: /opt/python/${{ matrix.PYTHON.VERSION }}/bin/python -m venv .venv
-      - name: Install Python dependencies
-        run: .venv/bin/pip install --require-hashes -r ${{ env.BUILD_REQUIREMENTS_PATH }}
 
       - uses: actions/download-artifact@fa0a91b85d4f404e444e00e005971372dc801d16 # v4.1.8
         with:
@@ -118,19 +115,15 @@ jobs:
       - name: Build the wheel
         run: |
           if [ -n "${{ matrix.PYTHON.ABI_VERSION }}" ]; then
-              PY_LIMITED_API="--config-settings=build-args=--features=pyo3/abi3-${{ matrix.PYTHON.ABI_VERSION }} --no-build-isolation"
+              PY_LIMITED_API="--config-settings=build-args=--features=pyo3/abi3-${{ matrix.PYTHON.ABI_VERSION }}"
           fi
 
-          # `maturin` has a binary that needs to be on the $PATH, so we
-          # activate the venv.
-          source .venv/bin/activate
           OPENSSL_DIR="/opt/pyca/cryptography/openssl" \
               OPENSSL_STATIC=1 \
-              .venv/bin/python -m pip wheel -v --no-deps $PY_LIMITED_API cryptograph*.tar.gz -w dist/
-          mv dist/cryptography*.whl tmpwheelhouse
+              uv build --python=/opt/python/${{ matrix.PYTHON.VERSION }}/bin/python --wheel --require-hashes --build-constraint=$BUILD_REQUIREMENTS_PATH $PY_LIMITED_API cryptography*.tar.gz -o tmpwheelhouse/
         env:
           RUSTUP_HOME: /root/.rustup
-      - run: auditwheel repair --plat ${{ matrix.MANYLINUX.NAME }} tmpwheelhouse/cryptograph*.whl -w wheelhouse/
+      - run: auditwheel repair --plat ${{ matrix.MANYLINUX.NAME }} tmpwheelhouse/cryptography*.whl -w wheelhouse/
       - run: unzip wheelhouse/*.whl -d execstack.check
       - run: |
           results=$(readelf -lW execstack.check/cryptography/hazmat/bindings/*.so)
@@ -140,15 +133,17 @@ jobs:
           else
             exit 0
           fi
-      - run: .venv/bin/pip install cryptography --no-index -f wheelhouse/
+
+      - run: uv venv --python=/opt/python/${{ matrix.PYTHON.VERSION }}/bin/python
+      - run: uv pip install --require-hashes -r $BUILD_REQUIREMENTS_PATH
+      - run: uv pip install cryptography --no-index -f wheelhouse/
       - run: |
-          .venv/bin/python -c "from cryptography.hazmat.backends.openssl.backend import backend;print('Loaded: ' + backend.openssl_version_text());print('Linked Against: ' + backend._ffi.string(backend._lib.OPENSSL_VERSION_TEXT).decode('ascii'))"
-      - run: mkdir cryptography-wheelhouse
-      - run: mv wheelhouse/cryptography*.whl cryptography-wheelhouse/
+          echo "from cryptography.hazmat.backends.openssl.backend import backend;print('Loaded: ' + backend.openssl_version_text());print('Linked Against: ' + backend._ffi.string(backend._lib.OPENSSL_VERSION_TEXT).decode('ascii'))" | uv run -
+
       - uses: actions/upload-artifact@50769540e7f4bd5e21e526ee35c689e35e0d6874 # v4.4.0
         with:
           name: "cryptography-${{ github.event.inputs.version }}-${{ matrix.MANYLINUX.NAME }}-${{ matrix.PYTHON.VERSION }}-${{ matrix.PYTHON.ABI_VERSION }}"
-          path: cryptography-wheelhouse/
+          path: wheelhouse/
 
   macos:
     needs: [sdist]